What Bryan Johnson’s Hyperbaric Oxygen Protocol Can Teach Us

If you’ve been following Bryan Johnson — the tech entrepreneur turned bio-optimization icon — you’ve likely seen his recent video on Hyperbaric Oxygen Therapy (HBOT). In it, he shares the profound benefits he’s experienced from incorporating HBOT into his intensive Blueprint protocol. It’s a compelling look into how this regenerative technology is making waves in the longevity space.
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But it also raises an important question:
What would it look like if therapies like HBOT weren’t just for billionaires, but part of everyday proactive care?

At AYUN, we’re working on that answer.

First, What is HBOT?

Hyperbaric Oxygen Therapy involves breathing 100% pure oxygen in a pressurized environment. This elevated oxygen level allows more oxygen to dissolve in your blood plasma, reaching areas that are otherwise under-oxygenated, stimulating cellular repair, and enhancing tissue regeneration.

HBOT is well-established in clinical medicine for wound healing, radiation damage, tissue repair and even certain infections. But in recent years, it has moved into the performance and longevity spotlight for its ability to:

• Enhance mitochondrial function: Long-term HBOT improves mitochondrial activity and reduces reactive oxygen species levels, enhancing energy production and cellular health. [1] [2]
• Improve cognitive function: HBOT has been shown to improve cerebral blood flow, brain metabolism, and brain microstructure, leading to improved cognitive functions. [3]
• Reduce inflammation: HBOT can decrease inflammatory markers and oxidative stress, contributing to reduced chronic inflammation. [4]
• Mobilize stem cells: HBOT increases the number of circulating stem/progenitor cells, which play a crucial role in tissue repair and regeneration. [5]‍
• Reverse biological aging markers: A study found that repeated daily HBOT sessions can increase telomere length by more than 20% and decrease the number of senescent cells in aging populations. [6]

What Bryan Johnson Found

In his video, Bryan shares how HBOT fits into his ultra-structured longevity protocol. Key takeaways include:

• He uses HBOT not only for healing but for prevention and performance
• He emphasizes its impact on cognitive clarity, energy, and systemic recovery
• He commits to long, structured protocols – sometimes 40–60 sessions
• Importantly, he acknowledges how time- and cost-intensive this therapy can be — and how many people may not have access to it in a meaningful, sustainable way.

This is where we at AYUN come in.

AYUN’s Approach: Precision Meets Practicality

We offer HBOT as part of our evidence-based, medically supervised longevity toolkit — not as a luxury add-on, but as a tool strategically integrated into a personalized plan.

What makes our model different?

• We don’t just offer HBOT — we determine who actually benefits from it (via physiological testing, VO2max, oxidative stress markers, or DNA predispositions)
• We pair HBOT with other synergistic therapies like IHHT, red light, cold exposure, and metabolic tracking
• We provide it within a framework of scientific interpretation and clinical follow-up, not as an isolated session

Our mission is to take the science of longevity and translate it into personalized, realistic pathways for those who are proactive but don’t have infinite time or resources.

Bryan Johnson’s work brings valuable attention to therapies like HBOT, and we applaud the precision with which he explores the future of human health. At AYUN, we want to ensure that this future isn’t just reserved for the few, but thoughtfully adapted for the many. Because longevity shouldn’t be a luxury. It should be a choice — powered by science, delivered with care, and adapted to your life.

Ready to experience the benefits of HBOT ?

👉 Book now